Royal Air Force Typhoon FGR4s have joined forces with French aircraft in a combined operation on an underground arms cache in Syrian territory employed by the IS group, according to the British defence ministry.
The location, identified by reconnaissance, was assessed as containing munitions and bombs, the announcement noted, and was located in hills just to the north of the historic site of Palmyra in the heart of Syria.
"The RAF jets used laser-guided Paveway IV weapons to target a several approach shafts down to the depot... early reports indicate the strike was effective," the MoD said.
There was no indication of any harm to civilians in the strike conducted Saturday night and every plane involved returned safely, the MoD added.
The British jets were assisted by a Voyager refuelling tanker.
IS - alternatively referred to as ISIS - enforced militant control over significant areas in Iraq and Syria before its territorial defeat in 2019.
"This operation demonstrates our UK leadership, and determination to work closely with our allies, to eliminate any resurgence of the terrorist group and their harmful and extremist ideologies in the Middle East," the British Defence Secretary the Defence Secretary remarked.
British military aircraft have conducted surveillance missions over Syrian airspace to "prevent any attempted resurgence" of IS after its routing at the Baghuz confrontation in 2019, the MoD reported.
"I must thank all the members of our armed forces participating in this strike for their skill and their valour," the Defence Secretary added. "Including them were thousands of British personnel deployed over the festive period. This action, to take out terrorist threats who endanger our security, shows how UK forces are always on standby, all year round, ensuring Britain's security domestically and strong abroad."
During December, the American forces conducted what it called a "massive strike" targeting Islamic State objectives in the country, following an attack resulted in the deaths of two American soldiers and a civilian linguist in Palmyra.
The UN says IS still maintains between 5,000 and 7,000 militants in Iraq and Syria.